Probing the Mec1(ATR) Checkpoint Activation Mechanism with Small Peptides

Yeast Mec1, the ortholog of human ATR, is the apical protein kinase that initiates the cell cycle checkpoint in response to DNA damage and replication stress. The basal activity of Mec1 kinase is activated by cell cycle phase-specific activators. Three distinct activators stimulate Mec1 kinase using...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Wanrooij, Paulina H., Tannous, Elias, Kumar, Sandeep, Navadgi-Patil, Vasundhara M., Burgers, Peter M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2016
Ämnen:
DNA and Chromosomes
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697174/
https://ncbi.nlm.nih.gov/pubmed/26499799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.687145
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