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A tale of two tails: Activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1

The DNA damage and replication checkpoint kinase Mec1/ATR is a member of the PI3-kinase related kinases that function in response to various genotoxic stresses. The checkpoint clamp 9-1-1 (Rad9-Rad1-Hus1 in S. pombe and mammals; Ddc1-Rad17-Mec3 in S. cerevisiae) executes two distinct checkpoint func...

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Bibliografske podrobnosti
Main Authors: Navadgi-Patil, Vasundhara M., Burgers, Peter M.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725207/
https://ncbi.nlm.nih.gov/pubmed/19464966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2009.03.011
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