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Probing the Mec1(ATR) Checkpoint Activation Mechanism with Small Peptides
Yeast Mec1, the ortholog of human ATR, is the apical protein kinase that initiates the cell cycle checkpoint in response to DNA damage and replication stress. The basal activity of Mec1 kinase is activated by cell cycle phase-specific activators. Three distinct activators stimulate Mec1 kinase using...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4697174/ https://ncbi.nlm.nih.gov/pubmed/26499799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.687145 |
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