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Mechanism of Auto-inhibition and Activation of Mec1(ATR) Checkpoint Kinase
In response to DNA damage or replication fork stalling, the basal activity of Saccharomyces cerevisiae Mec1(ATR) is stimulated in a cell cycle dependent manner, leading to cell cycle arrest and promoting DNA repair. Mec1(ATR) dysfunction leads to cell death in yeast and causes chromosome instability...
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| Gepubliceerd in: | Nat Struct Mol Biol |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2020
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7855233/ https://ncbi.nlm.nih.gov/pubmed/33169019 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-00522-0 |
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