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Mechanism of Auto-inhibition and Activation of Mec1(ATR) Checkpoint Kinase
In response to DNA damage or replication fork stalling, the basal activity of Saccharomyces cerevisiae Mec1(ATR) is stimulated in a cell cycle dependent manner, leading to cell cycle arrest and promoting DNA repair. Mec1(ATR) dysfunction leads to cell death in yeast and causes chromosome instability...
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| Publicado en: | Nat Struct Mol Biol |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7855233/ https://ncbi.nlm.nih.gov/pubmed/33169019 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-00522-0 |
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