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The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint
Yeast Mec1/Ddc2 protein kinase, the ortholog of human ATR/ATRIP, plays a central role in the DNA-damage checkpoint. The PCNA-like clamp Rad17/Mec3/Ddc1 (the 9-1-1 complex in human) and its loader Rad24-RFC are also essential components of this signal transduction pathway. Here we have studied the ro...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1850967/ https://ncbi.nlm.nih.gov/pubmed/17189191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2006.11.027 |
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