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The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint

Yeast Mec1/Ddc2 protein kinase, the ortholog of human ATR/ATRIP, plays a central role in the DNA-damage checkpoint. The PCNA-like clamp Rad17/Mec3/Ddc1 (the 9-1-1 complex in human) and its loader Rad24-RFC are also essential components of this signal transduction pathway. Here we have studied the ro...

詳細記述

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書誌詳細
主要な著者: Majka, Jerzy, Niedziela-Majka, Anita, Burgers, Peter M. J.
フォーマット: Artigo
言語:Inglês
出版事項: 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850967/
https://ncbi.nlm.nih.gov/pubmed/17189191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2006.11.027
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