Dynamics of a Benzo[a]pyrene-derived Guanine DNA Lesion in TGT and CGC Sequence Contexts: Enhanced Mobility in TGT Explains Conformational Heterogeneity, Flexible Bending, and Greater Susceptibility to Nucleotide Excision Repair

The nucleotide excision repair (NER) machinery excises a variety of bulky DNA lesions, but with varying efficiencies. The structural features of the DNA lesions that govern these differences are not well understood. An intriguing model system for studying structure–function relationships in NER is t...

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Bibliografiska uppgifter
I publikationen:J Mol Biol
Huvudupphovsmän: Cai, Yuqin, Patel, Dinshaw J., Geacintov, Nicholas E., Broyde, Suse
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2007
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4693642/
https://ncbi.nlm.nih.gov/pubmed/17942115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.09.034
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