Combinatorial therapeutic activation with heparin and AICAR stimulates additive effects on utrophin A expression in dystrophic muscles

Upregulation of utrophin A is an attractive therapeutic strategy for treating Duchenne muscular dystrophy (DMD). Over the years, several studies revealed that utrophin A is regulated by multiple transcriptional and post-transcriptional mechanisms, and that pharmacological modulation of these pathway...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Principais autores: Péladeau, Christine, Ahmed, Aatika, Amirouche, Adel, Crawford Parks, Tara E., Bronicki, Lucas M., Ljubicic, Vladimir, Renaud, Jean-Marc, Jasmin, Bernard J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4690489/
https://ncbi.nlm.nih.gov/pubmed/26494902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv444
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