Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles

Up-regulation of utrophin in muscles represents a promising therapeutic strategy for the treatment of Duchenne Muscular Dystrophy. We previously demonstrated that eEF1A2 associates with the 5’UTR of utrophin A to promote IRES-dependent translation. Here, we examine whether eEF1A2 directly regulates...

詳細記述

保存先:
書誌詳細
出版年:Nat Commun
主要な著者: Péladeau, Christine, Adam, Nadine, Bronicki, Lucas M., Coriati, Adèle, Thabet, Mohamed, Al-Rewashdy, Hasanen, Vanstone, Jason, Mears, Alan, Renaud, Jean-Marc, Holcik, Martin, Jasmin, Bernard J.
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2020
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181625/
https://ncbi.nlm.nih.gov/pubmed/32332749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15971-w
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