Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles

Up-regulation of utrophin in muscles represents a promising therapeutic strategy for the treatment of Duchenne Muscular Dystrophy. We previously demonstrated that eEF1A2 associates with the 5’UTR of utrophin A to promote IRES-dependent translation. Here, we examine whether eEF1A2 directly regulates...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Nat Commun
Main Authors: Péladeau, Christine, Adam, Nadine, Bronicki, Lucas M., Coriati, Adèle, Thabet, Mohamed, Al-Rewashdy, Hasanen, Vanstone, Jason, Mears, Alan, Renaud, Jean-Marc, Holcik, Martin, Jasmin, Bernard J.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181625/
https://ncbi.nlm.nih.gov/pubmed/32332749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15971-w
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares