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Crosstalk between RyR2 Oxidation and Phosphorylation Contributes to Cardiac dysfunction in Mice with Duchenne Muscular Dystrophy

BACKGROUND: Patients with Duchenne muscular dystrophy (DMD) are at risk of developing cardiomyopathy and cardiac arrhythmias. Studies in a mouse model of DMD revealed that enhanced sarcoplasmic reticulum (SR) Ca(2+) leak contributes to the pathogenesis of cardiac dysfunction. In view of recent data...

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Vydáno v:J Mol Cell Cardiol
Hlavní autoři: Wang, Qiongling, Wang, Wei, Wang, Guoliang, Rodney, George, Wehrens, Xander H.T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689641/
https://ncbi.nlm.nih.gov/pubmed/26555638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.11.009
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