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ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT(2) Domain with γH2AX
53BP1 plays multiple roles in mammalian DNA damage repair, mediating pathway choice and facilitating DNA double-strand break repair in heterochromatin. Although it possesses a C-terminal BRCT(2) domain, commonly involved in phospho-peptide binding in other proteins, initial recruitment of 53BP1 to s...
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| Опубликовано в: : | Cell Rep |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Cell Press
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4688034/ https://ncbi.nlm.nih.gov/pubmed/26628370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.10.074 |
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