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53BP1 promotes ATM activity through direct interactions with the MRN complex

The Mre11/Rad50/Nbs1 (MRN) complex has a central function in facilitating activation of the ATM protein kinase at sites of DNA double-strand breaks (DSBs). However, several other factors are also required in human cells for efficient signalling through MRN and ATM, including the tumour suppressor pr...

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Detalhes bibliográficos
Main Authors: Lee, Ji-Hoon, Goodarzi, Aaron A, Jeggo, Penny A, Paull, Tanya T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830698/
https://ncbi.nlm.nih.gov/pubmed/20010693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.372
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