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53BP1 promotes ATM activity through direct interactions with the MRN complex
The Mre11/Rad50/Nbs1 (MRN) complex has a central function in facilitating activation of the ATM protein kinase at sites of DNA double-strand breaks (DSBs). However, several other factors are also required in human cells for efficient signalling through MRN and ATM, including the tumour suppressor pr...
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| Huvudupphovsmän: | , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Nature Publishing Group
2010
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2830698/ https://ncbi.nlm.nih.gov/pubmed/20010693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.372 |
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