ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT(2) Domain with γH2AX

53BP1 plays multiple roles in mammalian DNA damage repair, mediating pathway choice and facilitating DNA double-strand break repair in heterochromatin. Although it possesses a C-terminal BRCT(2) domain, commonly involved in phospho-peptide binding in other proteins, initial recruitment of 53BP1 to s...

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Pubblicato in:Cell Rep
Autori principali: Baldock, Robert A., Day, Matthew, Wilkinson, Oliver J., Cloney, Ross, Jeggo, Penelope A., Oliver, Antony W., Watts, Felicity Z., Pearl, Laurence H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2015
Soggetti:
Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4688034/
https://ncbi.nlm.nih.gov/pubmed/26628370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.10.074
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