JAK2V617F-mediated phosphorylation of PRMT5 down-regulates its methyltransferase activity and promotes myeloproliferation

The JAK2V617F constitutively activated tyrosine kinase is found in most patients with myeloproliferative neoplasms. While examining the interaction between JAK2 and PRMT5, an arginine methyltransferase originally identified as JAK2 binding protein 1, we found that JAK2V617F (and JAK2K539L) bound PRM...

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Publicado en:Cancer Cell
Main Authors: Liu, Fan, Zhao, Xinyang, Perna, Fabiana, Wang, Lan, Koppikar, Priya, Abdel-Wahab, Omar, Harr, Michael W., Levine, Ross L., Xu, Hao, Tefferi, Ayalew, Deblasio, Anthony, Hatlen, Megan, Menendez, Silvia, Nimer, Stephen D.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687747/
https://ncbi.nlm.nih.gov/pubmed/21316606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.12.020
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