JAK2V617F-mediated phosphorylation of PRMT5 down-regulates its methyltransferase activity and promotes myeloproliferation

The JAK2V617F constitutively activated tyrosine kinase is found in most patients with myeloproliferative neoplasms. While examining the interaction between JAK2 and PRMT5, an arginine methyltransferase originally identified as JAK2 binding protein 1, we found that JAK2V617F (and JAK2K539L) bound PRM...

詳細記述

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書誌詳細
出版年:Cancer Cell
主要な著者: Liu, Fan, Zhao, Xinyang, Perna, Fabiana, Wang, Lan, Koppikar, Priya, Abdel-Wahab, Omar, Harr, Michael W., Levine, Ross L., Xu, Hao, Tefferi, Ayalew, Deblasio, Anthony, Hatlen, Megan, Menendez, Silvia, Nimer, Stephen D.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687747/
https://ncbi.nlm.nih.gov/pubmed/21316606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.12.020
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