Nobiletin enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cancer cells

Multidrug resistance (MDR) is the major obstacle to the successful chemotherapy treatment of many cancers. Here we found that nobiletin, a citrus methoxyflavone, significantly sensitized ABCB1 overexpressing cells A2780/T and A549/T to chemotherapeutic agents such as paclitaxel (a 433-fold reversal...

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Vydáno v:Sci Rep
Hlavní autoři: Ma, Wenzhe, Feng, Senling, Yao, Xiaojun, Yuan, Zhongwen, Liu, Liang, Xie, Ying
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686932/
https://ncbi.nlm.nih.gov/pubmed/26689156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18789
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