BIRB796, the Inhibitor of p38 Mitogen-Activated Protein Kinase, Enhances the Efficacy of Chemotherapeutic Agents in ABCB1 Overexpression Cells

ATP-binding-cassette family membrane proteins play an important role in multidrug resistance. In this study, we investigated BIRB796, an orally active inhibitor of p38 mitogen-activated protein kinase, reversed MDR induced by ABCB1, ABCG2 and ABCC1. Our results showed that BIRB796 could reverse ABCB...

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Detalhes bibliográficos
Main Authors: He, Dan, Zhao, Xiao-qin, Chen, Xing-gui, Fang, Yi, Singh, Satyakam, Talele, Tanaji T., Qiu, Hui-juan, Liang, Yong-ju, Wang, Xiao-kun, Zhang, Guo-qing, Chen, Zhe-sheng, Fu, Li-wu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548808/
https://ncbi.nlm.nih.gov/pubmed/23349819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054181
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