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Structural insights into the DNA-binding specificity of E2F family transcription factors

The mammalian cell cycle is controlled by the E2F family of transcription factors. Typical E2Fs bind to DNA as heterodimers with the related dimerization partner (DP) proteins, whereas the atypical E2Fs, E2F7 and E2F8 contain two DNA-binding domains (DBDs) and act as repressors. To understand the me...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Morgunova, Ekaterina, Yin, Yimeng, Jolma, Arttu, Dave, Kashyap, Schmierer, Bernhard, Popov, Alexander, Eremina, Nadejda, Nilsson, Lennart, Taipale, Jussi
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686757/
https://ncbi.nlm.nih.gov/pubmed/26632596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10050
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