Intrinsic Resistance to Cixutumumab is Conferred by Distinct Isoforms of the Insulin Receptor

Despite a recent shift away from anti-insulin-like growth factor I receptor (IGF-IR) therapy, this target has been identified as a key player in the resistance mechanisms to various conventional and targeted agents, emphasizing its value as a therapy, provided that it is used in the right patient po...

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Détails bibliographiques
Publié dans:Mol Cancer Res
Auteurs principaux: Forest, Amelie, Amatulli, Michael, Ludwig, Dale L., Damoci, Christopher B., Wang, Ying, Burns, Colleen A., Donoho, Gregory P., Zanella, Nina, Fiebig, Heinz H., Prewett, Marie C., Surguladze, David, DeLigio, James T., Houghton, Peter J., Smith, Malcolm A., Novosiadly, Ruslan
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685019/
https://ncbi.nlm.nih.gov/pubmed/26263910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-15-0279
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