A human monoclonal antibody targeting the stem cell factor receptor (c-Kit) blocks tumor cell signaling and inhibits tumor growth

Stem cell factor receptor (c-Kit) exerts multiple biological effects on target cells upon binding its ligand stem cell factor (SCF). Aberrant activation of c-Kit results in dysregulated signaling and is implicated in the pathogenesis of numerous cancers. The development of more specific and effectiv...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Lebron, Maria B, Brennan, Laura, Damoci, Christopher B, Prewett, Marie C, O’Mahony, Marguerita, Duignan, Inga J, Credille, Kelly M, DeLigio, James T, Starodubtseva, Marina, Amatulli, Michael, Zhang, Yiwei, Schwartz, Kaben D, Burtrum, Douglas, Balderes, Paul, Persaud, Kris, Surguladze, David, Loizos, Nick, Paz, Keren, Kotanides, Helen
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Landes Bioscience 2014
Θέματα:
Research Paper
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128863/
https://ncbi.nlm.nih.gov/pubmed/24921944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.29523
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