A human monoclonal antibody targeting the stem cell factor receptor (c-Kit) blocks tumor cell signaling and inhibits tumor growth

Stem cell factor receptor (c-Kit) exerts multiple biological effects on target cells upon binding its ligand stem cell factor (SCF). Aberrant activation of c-Kit results in dysregulated signaling and is implicated in the pathogenesis of numerous cancers. The development of more specific and effectiv...

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Detaylı Bibliyografya
Asıl Yazarlar: Lebron, Maria B, Brennan, Laura, Damoci, Christopher B, Prewett, Marie C, O’Mahony, Marguerita, Duignan, Inga J, Credille, Kelly M, DeLigio, James T, Starodubtseva, Marina, Amatulli, Michael, Zhang, Yiwei, Schwartz, Kaben D, Burtrum, Douglas, Balderes, Paul, Persaud, Kris, Surguladze, David, Loizos, Nick, Paz, Keren, Kotanides, Helen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Landes Bioscience 2014
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128863/
https://ncbi.nlm.nih.gov/pubmed/24921944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.29523
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