A human monoclonal antibody targeting the stem cell factor receptor (c-Kit) blocks tumor cell signaling and inhibits tumor growth

Stem cell factor receptor (c-Kit) exerts multiple biological effects on target cells upon binding its ligand stem cell factor (SCF). Aberrant activation of c-Kit results in dysregulated signaling and is implicated in the pathogenesis of numerous cancers. The development of more specific and effectiv...

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Detalhes bibliográficos
Principais autores: Lebron, Maria B, Brennan, Laura, Damoci, Christopher B, Prewett, Marie C, O’Mahony, Marguerita, Duignan, Inga J, Credille, Kelly M, DeLigio, James T, Starodubtseva, Marina, Amatulli, Michael, Zhang, Yiwei, Schwartz, Kaben D, Burtrum, Douglas, Balderes, Paul, Persaud, Kris, Surguladze, David, Loizos, Nick, Paz, Keren, Kotanides, Helen
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128863/
https://ncbi.nlm.nih.gov/pubmed/24921944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.29523
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