Development of a Fully Human Anti-PDGFRβ Antibody That Suppresses Growth of Human Tumor Xenografts and Enhances Antitumor Activity of an Anti-VEGFR2 Antibody

Platelet-derived growth factor receptor β (PDGFRβ) is upregulated in most of solid tumors. It is expressed by pericytes/smooth muscle cells, fibroblast, macrophage, and certain tumor cells. Several PDGF receptor-related antagonists are being developed as potential antitumor agents and have demonstra...

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Detalhes bibliográficos
Main Authors: Shen, Juqun, Vil, Marie Danielle, Prewett, Marie, Damoci, Chris, Zhang, Haifan, Li, Huiling, Jimenez, Xenia, Deevi, Dhanvanthri S, Iacolina, Michelle, Kayas, Anthony, Bassi, Rajiv, Persaud, Kris, Rohoza-Asandi, Anna, Balderes, Paul, Loizos, Nick, Ludwig, Dale L, Tonra, James, Witte, Larry, Zhu, Zhenping
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685448/
https://ncbi.nlm.nih.gov/pubmed/19484148
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