A bi-functional antibody-receptor domain fusion protein simultaneously targeting IGF-IR and VEGF for degradation

Bi-specific antibodies (BsAbs), which can simultaneously block 2 tumor targets, have emerged as promising therapeutic alternatives to combinations of individual monoclonal antibodies. Here, we describe the engineering and development of a novel, human bi-functional antibody-receptor domain fusion mo...

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書誌詳細
出版年:MAbs
主要な著者: Shen, Yang, Zeng, Lin, Novosyadlyy, Ruslan, Forest, Amelie, Zhu, Aiping, Korytko, Andrew, Zhang, Haifan, Eastman, Scott W, Topper, Michael, Hindi, Sagit, Covino, Nicole, Persaud, Kris, Kang, Yun, Burtrum, Douglas, Surguladze, David, Prewett, Marie, Chintharlapalli, Sudhakar, Wroblewski, Victor J, Shen, Juqun, Balderes, Paul, Zhu, Zhenping, Snavely, Marshall, Ludwig, Dale L
フォーマット: Artigo
言語:Inglês
出版事項: Taylor & Francis 2015
主題:
Report
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623440/
https://ncbi.nlm.nih.gov/pubmed/26073904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1055442
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