Molecular basis for necitumumab inhibition of EGFR variants associated with acquired cetuximab resistance

Acquired resistance to cetuximab, an antibody that targets the epidermal growth factor receptor (EGFR), impacts clinical benefit in head and neck, and colorectal cancers (CRC). One of the mechanisms of resistance to cetuximab is the acquisition of mutations that map to the cetuximab epitope on EGFR...

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Udgivet i:Mol Cancer Ther
Main Authors: Bagchi, Atrish, Haidar, Jaafar N., Eastman, Scott W., Vieth, Michal, Topper, Michael, Iacolina, Michelle D., Walker, Jason M., Forest, Amelie, Shen, Yang, Novosiadly, Ruslan D., Ferguson, Kathryn M.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5925748/
https://ncbi.nlm.nih.gov/pubmed/29158469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0575
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