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Structural evaluation of EGFR inhibition mechanisms for nanobodies/VHH domains
The epidermal growth factor receptor (EGFR) is implicated in human cancers and is the target of several classes of therapeutic agents, including antibody-based drugs. Here, we describe X-ray crystal structures of the extracellular region of EGFR in complex with three inhibitory VHH domains or nanobo...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3733345/ https://ncbi.nlm.nih.gov/pubmed/23791944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.05.008 |
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