CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells

The important family of G protein-coupled receptors has so far not been targeted very successfully with conventional monoclonal antibodies. Here we report the isolation and characterization of functional VHH-based immunoglobulin single variable domains (or nanobodies) against the chemokine receptor...

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Detalhes bibliográficos
Main Authors: Jähnichen, Sven, Blanchetot, Christophe, Maussang, David, Gonzalez-Pajuelo, Maria, Chow, Ken Y., Bosch, Leontien, De Vrieze, Sindi, Serruys, Benedikte, Ulrichts, Hans, Vandevelde, Wesly, Saunders, Michael, De Haard, Hans J., Schols, Dominique, Leurs, Rob, Vanlandschoot, Peter, Verrips, Theo, Smit, Martine J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996674/
https://ncbi.nlm.nih.gov/pubmed/21059953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012865107
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