Neutralizing Nanobodies Targeting Diverse Chemokines Effectively Inhibit Chemokine Function

Chemokine receptors and their ligands play a prominent role in immune regulation but many have also been implicated in inflammatory diseases such as multiple sclerosis, rheumatoid arthritis, allograft rejection after transplantation, and also in cancer metastasis. Most approaches to therapeutically...

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Autors principals: Blanchetot, Christophe, Verzijl, Dennis, Mujić-Delić, Azra, Bosch, Leontien, Rem, Louise, Leurs, Rob, Verrips, C. Theo, Saunders, Michael, de Haard, Hans, Smit, Martine J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757181/
https://ncbi.nlm.nih.gov/pubmed/23836909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.467969
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