Neutralization of Human Interleukin 23 by Multivalent Nanobodies Explained by the Structure of Cytokine–Nanobody Complex

The heterodimeric cytokine interleukin (IL) 23 comprises the IL12-shared p40 subunit and an IL23-specific subunit, p19. Together with IL12 and IL27, IL23 sits at the apex of the regulatory mechanisms shaping adaptive immune responses. IL23, together with IL17, plays an important role in the developm...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Desmyter, Aline, Spinelli, Silvia, Boutton, Carlo, Saunders, Michael, Blachetot, Christophe, de Haard, Hans, Denecker, Geertrui, Van Roy, Maarten, Cambillau, Christian, Rommelaere, Heidi
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566574/
https://ncbi.nlm.nih.gov/pubmed/28871249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00884
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