Neutralizing Nanobodies Targeting Diverse Chemokines Effectively Inhibit Chemokine Function

Chemokine receptors and their ligands play a prominent role in immune regulation but many have also been implicated in inflammatory diseases such as multiple sclerosis, rheumatoid arthritis, allograft rejection after transplantation, and also in cancer metastasis. Most approaches to therapeutically...

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Autores principales: Blanchetot, Christophe, Verzijl, Dennis, Mujić-Delić, Azra, Bosch, Leontien, Rem, Louise, Leurs, Rob, Verrips, C. Theo, Saunders, Michael, de Haard, Hans, Smit, Martine J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757181/
https://ncbi.nlm.nih.gov/pubmed/23836909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.467969
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