CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells

The important family of G protein-coupled receptors has so far not been targeted very successfully with conventional monoclonal antibodies. Here we report the isolation and characterization of functional VHH-based immunoglobulin single variable domains (or nanobodies) against the chemokine receptor...

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Main Authors: Jähnichen, Sven, Blanchetot, Christophe, Maussang, David, Gonzalez-Pajuelo, Maria, Chow, Ken Y., Bosch, Leontien, De Vrieze, Sindi, Serruys, Benedikte, Ulrichts, Hans, Vandevelde, Wesly, Saunders, Michael, De Haard, Hans J., Schols, Dominique, Leurs, Rob, Vanlandschoot, Peter, Verrips, Theo, Smit, Martine J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996674/
https://ncbi.nlm.nih.gov/pubmed/21059953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012865107
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