CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells

The important family of G protein-coupled receptors has so far not been targeted very successfully with conventional monoclonal antibodies. Here we report the isolation and characterization of functional VHH-based immunoglobulin single variable domains (or nanobodies) against the chemokine receptor...

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Main Authors: Jähnichen, Sven, Blanchetot, Christophe, Maussang, David, Gonzalez-Pajuelo, Maria, Chow, Ken Y., Bosch, Leontien, De Vrieze, Sindi, Serruys, Benedikte, Ulrichts, Hans, Vandevelde, Wesly, Saunders, Michael, De Haard, Hans J., Schols, Dominique, Leurs, Rob, Vanlandschoot, Peter, Verrips, Theo, Smit, Martine J.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2010
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996674/
https://ncbi.nlm.nih.gov/pubmed/21059953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012865107
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