Transient receptor potential channel 1 maintains adherens junction plasticity by suppressing sphingosine kinase 1 expression to induce endothelial hyperpermeability

Stability of endothelial cell (EC) adherens junctions (AJs) is central for prevention of tissue edema, the hallmark of chronic inflammatory diseases including acute respiratory distress syndrome. Here, we demonstrate a previously unsuspected role of sphingosine kinase 1 (SPHK1) in the mechanism by w...

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Bibliografske podrobnosti
izdano v:FASEB J
Main Authors: Tauseef, Mohammad, Farazuddin, Mohammad, Sukriti, Sukriti, Rajput, Charu, Meyer, James Otto, Ramasamy, Suresh Kumar, Mehta, Dolly
Format: Artigo
Jezik:Inglês
Izdano: Federation of American Societies for Experimental Biology 2016
Teme:
Research Communication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684542/
https://ncbi.nlm.nih.gov/pubmed/26316271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-275891
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