The G protein βγ subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin

The inflammatory mediator thrombin proteolytically activates protease-activated receptor (PAR1) eliciting a transient, but reversible increase in vascular permeability. PAR1-induced dissociation of Gα subunit from heterotrimeric Gq and G12/G13 proteins is known to signal the increase in endothelial...

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Hlavní autoři: Knezevic, Nebojsa, Tauseef, Mohammad, Thennes, Tracy, Mehta, Dolly
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806626/
https://ncbi.nlm.nih.gov/pubmed/19917775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090652
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