Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions

Increased pulmonary microvessel pressure experienced in left heart failure, head trauma, or high altitude can lead to endothelial barrier disruption referred to as capillary “stress failure” that causes leakage of protein-rich plasma and pulmonary edema. However, little is known about vascular endot...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Friedrich, Emily E., Hong, Zhigang, Xiong, Shiqin, Zhong, Ming, Di, Anke, Rehman, Jalees, Komarova, Yulia A., Malik, Asrar B.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6600969/
https://ncbi.nlm.nih.gov/pubmed/31186359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902165116
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