Alveolar Stretch Activation of Endothelial Piezo1 Protects Adherens Junctions and Lung Vascular Barrier

Disruption of alveolar–capillary barriers is a major complication of high-volume mechanical ventilation referred to as “ventilator-induced lung injury.” The stretching force in alveoli is transmitted to endothelial cells, increasing the tension on underlying endothelial plasma membrane. The mechanos...

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Bibliografiske detaljer
Udgivet i:Am J Respir Cell Mol Biol
Main Authors: Zhong, Ming, Wu, Wei, Kang, Hojin, Hong, Zhigang, Xiong, Shiqin, Gao, Xiaopei, Rehman, Jalees, Komarova, Yulia A., Malik, Asrar B.
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2020
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6993544/
https://ncbi.nlm.nih.gov/pubmed/31409093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2019-0024OC
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