Alveolar Stretch Activation of Endothelial Piezo1 Protects Adherens Junctions and Lung Vascular Barrier

Disruption of alveolar–capillary barriers is a major complication of high-volume mechanical ventilation referred to as “ventilator-induced lung injury.” The stretching force in alveoli is transmitted to endothelial cells, increasing the tension on underlying endothelial plasma membrane. The mechanos...

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Bibliographic Details
Published in:Am J Respir Cell Mol Biol
Main Authors: Zhong, Ming, Wu, Wei, Kang, Hojin, Hong, Zhigang, Xiong, Shiqin, Gao, Xiaopei, Rehman, Jalees, Komarova, Yulia A., Malik, Asrar B.
Format: Artigo
Language:Inglês
Published: American Thoracic Society 2020
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6993544/
https://ncbi.nlm.nih.gov/pubmed/31409093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2019-0024OC
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