Transient receptor potential channel 1 maintains adherens junction plasticity by suppressing sphingosine kinase 1 expression to induce endothelial hyperpermeability

Stability of endothelial cell (EC) adherens junctions (AJs) is central for prevention of tissue edema, the hallmark of chronic inflammatory diseases including acute respiratory distress syndrome. Here, we demonstrate a previously unsuspected role of sphingosine kinase 1 (SPHK1) in the mechanism by w...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Tauseef, Mohammad, Farazuddin, Mohammad, Sukriti, Sukriti, Rajput, Charu, Meyer, James Otto, Ramasamy, Suresh Kumar, Mehta, Dolly
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2016
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684542/
https://ncbi.nlm.nih.gov/pubmed/26316271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-275891
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