Transient receptor potential channel 1 maintains adherens junction plasticity by suppressing sphingosine kinase 1 expression to induce endothelial hyperpermeability

Stability of endothelial cell (EC) adherens junctions (AJs) is central for prevention of tissue edema, the hallmark of chronic inflammatory diseases including acute respiratory distress syndrome. Here, we demonstrate a previously unsuspected role of sphingosine kinase 1 (SPHK1) in the mechanism by w...

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Vydáno v:FASEB J
Hlavní autoři: Tauseef, Mohammad, Farazuddin, Mohammad, Sukriti, Sukriti, Rajput, Charu, Meyer, James Otto, Ramasamy, Suresh Kumar, Mehta, Dolly
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2016
Témata:
Research Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684542/
https://ncbi.nlm.nih.gov/pubmed/26316271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-275891
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