The Binding Interface Between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches

APOBEC3 family DNA cytosine deaminases provide overlapping defenses against pathogen infections. However, most viruses have elaborate evasion mechanisms such as the HIV-1 Vif protein, which subverts cellular CBF-β and a polyubiquitin ligase complex to neutralize these enzymes. Despite advances in AP...

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Publicat a:Cell Rep
Autors principals: Richards, Christopher, Albin, John S., Demir, Özlem, Shaban, Nadine M., Luengas, Elizabeth M., Land, Allison M., Anderson, Brett D., Holten, John R., Anderson, John S., Harki, Daniel A., Amaro, Rommie E., Harris, Reuben S.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684092/
https://ncbi.nlm.nih.gov/pubmed/26628363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.10.067
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