The Binding Interface Between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches

APOBEC3 family DNA cytosine deaminases provide overlapping defenses against pathogen infections. However, most viruses have elaborate evasion mechanisms such as the HIV-1 Vif protein, which subverts cellular CBF-β and a polyubiquitin ligase complex to neutralize these enzymes. Despite advances in AP...

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Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Richards, Christopher, Albin, John S., Demir, Özlem, Shaban, Nadine M., Luengas, Elizabeth M., Land, Allison M., Anderson, Brett D., Holten, John R., Anderson, John S., Harki, Daniel A., Amaro, Rommie E., Harris, Reuben S.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684092/
https://ncbi.nlm.nih.gov/pubmed/26628363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.10.067
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