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TCR signaling to NF-κB and mTORC1: expanding roles of the CARMA1 complex
Naïve T-cell activation requires signals from both the T-cell receptor (TCR) and the costimulatory molecule CD28. A central mediator of the TCR and CD28 signals is the scaffold protein CARMA1, which functions by forming a complex with partner proteins, Bcl10 and MALT1. A well-known function of the C...
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| Publié dans: | Mol Immunol |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4679546/ https://ncbi.nlm.nih.gov/pubmed/26260210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2015.07.024 |
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