Huntingtin Subcellular Localisation Is Regulated by Kinase Signalling Activity in the StHdh(Q111) Model of HD

Huntington’s disease is a neurodegenerative disorder characterised primarily by motor abnormalities, and is caused by an expanded polyglutamine repeat in the huntingtin protein. Huntingtin dynamically shuttles between subcellular compartments, and the mutant huntingtin protein is mislocalised to cel...

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Udgivet i:PLoS One
Main Authors: Bowles, Kathryn R., Brooks, Simon P., Dunnett, Stephen B., Jones, Lesley
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679340/
https://ncbi.nlm.nih.gov/pubmed/26660732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144864
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