Dual-Action Inhibitors of HIF Prolyl Hydroxylases That Induce Binding of a Second Iron Ion

Inhibition of the hypoxia-inducible factor (HIF) prolyl-hydroxylases (PHD or EGLN enzymes) is of interest for the treatment of anemia and ischemia-related diseases. Most PHD inhibitors work by binding to the single ferrous ion and competing with 2-oxoglutarate (2OG) co-substrate for binding at the P...

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Detalhes bibliográficos
Publicado no:Org Biomol Chem
Main Authors: Yeoh, Kar Kheng, Chan, Mun Chiang, Thalhammer, Armin, Demetriades, Marina, Chowdhury, Rasheduzzaman, Tian, Ya-Min, Stolze, Ineke, McNeill, Luke A., Lee, Myung Kyu, Woon, Esther C. Y., Mackeen, Mukram M., Kawamura, Akane, Ratcliffe, Peter J., Mecinović, Jasmin, Schofield, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677462/
https://ncbi.nlm.nih.gov/pubmed/23151668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2ob26648b
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