K-Ras stabilization by estrogen via PKCδ is involved in endometrial tumorigenesis

Estrogens are considered as a major risk factor of endometrial cancer. In this study, we identified a mechanism of tumorigenesis in which K-Ras protein is stabilized via estrogen signaling through the ER-α36 receptor. PKCδ was shown to stabilize K-Ras specifically via estrogen signaling. Estrogens s...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Koo, Kyoung-Hwa, Jeong, Woo-Jeong, Cho, Yong-Hee, Park, Jong-Chan, Min, Do Sik, Choi, Kang-Yell
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673268/
https://ncbi.nlm.nih.gov/pubmed/26015399
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