WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer

Abstract Background Stabilization of RAS is a key event for the hyper-activation of Wnt/β-catenin signaling and activation of cancer stem cell (CSC) in colorectal cancer (CRC). WD Repeat protein 76 (WDR76) mediates the polyubiquitination-dependent degradation of RAS in hepatocellular carcinoma (HCC)...

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Main Authors: Eun Ji Ro, Yong-Hee Cho, Woo-Jeong Jeong, Jong-Chan Park, Do Sik Min, Kang-Yell Choi
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2019-07-01
Series:Cell Communication and Signaling
Assuntos:
Colorectal Cancer
RAS stability
WDR76
Cancer stem cell
Tumor suppressor
Acceso en liña:http://link.springer.com/article/10.1186/s12964-019-0403-x
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