WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer

BACKGROUND: Stabilization of RAS is a key event for the hyper-activation of Wnt/β-catenin signaling and activation of cancer stem cell (CSC) in colorectal cancer (CRC). WD Repeat protein 76 (WDR76) mediates the polyubiquitination-dependent degradation of RAS in hepatocellular carcinoma (HCC). We inv...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Commun Signal
Main Authors: Ro, Eun Ji, Cho, Yong-Hee, Jeong, Woo-Jeong, Park, Jong-Chan, Min, Do Sik, Choi, Kang-Yell
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668196/
https://ncbi.nlm.nih.gov/pubmed/31362761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0403-x
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados