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WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer
BACKGROUND: Stabilization of RAS is a key event for the hyper-activation of Wnt/β-catenin signaling and activation of cancer stem cell (CSC) in colorectal cancer (CRC). WD Repeat protein 76 (WDR76) mediates the polyubiquitination-dependent degradation of RAS in hepatocellular carcinoma (HCC). We inv...
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| Publicat a: | Cell Commun Signal |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6668196/ https://ncbi.nlm.nih.gov/pubmed/31362761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0403-x |
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