WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation

Stability regulation of RAS that can affect its activity, in addition to the oncogenic mutations, occurs in human cancer. However, the mechanisms for stability regulation of RAS involved in their activity and its roles in tumorigenesis are poorly explored. Here, we identify WD40-repeat protein 76 (W...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Jeong, Woo-Jeong, Park, Jong-Chan, Kim, Woo-Shin, Ro, Eun Ji, Jeon, Soung Hoo, Lee, Sang-Kyu, Park, Young Nyun, Min, Do Sik, Choi, Kang-Yell
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6336889/
https://ncbi.nlm.nih.gov/pubmed/30655611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08230-6
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