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Interaction between Wnt/β-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of β-catenin and RAS by targeting the Wnt/β-catenin pathway

Aberrant activation of the Wnt/β-catenin and RAS-extracellular signal-regulated kinase (ERK) pathways play important roles in the tumorigenesis of many different types of cancer, most notably colorectal cancer (CRC). Genes for these two pathways, such as adenomatous polyposis coli (APC) and KRAS are...

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Detalhes bibliográficos
Publicado no:NPJ Precis Oncol
Main Authors: Jeong, Woo-Jeong, Ro, Eun Ji, Choi, Kang-Yell
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871897/
https://ncbi.nlm.nih.gov/pubmed/29872723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41698-018-0049-y
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