Destabilization of β-catenin and RAS by targeting the Wnt/β-catenin pathway as a potential treatment for triple-negative breast cancer

Triple-negative breast cancer (TNBC) is a severe and heterogeneous disease that lacks an approved targeted therapy and has a poor clinical outcome to chemotherapy. Although the RAS-ERK signaling axis is rarely mutated in TNBC, ~50% of TNBCs show an increased copy number and overexpression of epiderm...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Exp Mol Med
Hoofdauteurs: Ryu, Won-Ji, Lee, Jeong Dong, Park, Jong-Chan, Cha, Pu-Hyeon, Cho, Yong-Hee, Kim, Jee Ye, Sohn, Joo Hyuk, Paik, Soonmyung, Choi, Kang-Yell
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272395/
https://ncbi.nlm.nih.gov/pubmed/32457491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-020-0440-y
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items