Simultaneous destabilization of β-catenin and Ras via targeting of the axin-RGS domain as a potential therapeutic strategy for colorectal cancer

Mutations of APC and KRAS are frequently observed in human colorectal cancers (CRCs) and the Wnt/β-catenin and Ras pathways are consequently activated in a significant proportion of CRC patients. Mutations in these two genes are also known to synergistically induce progression of CRCs. Through a ser...

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Bibliographic Details
Published in:BMB Rep
Main Authors: Cha, Pu-Hyeon, Choi, Kang-Yell
Format: Artigo
Language:Inglês
Published: Korean Society for Biochemistry and Molecular Biology 2016
Subjects:
Perspective
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5227137/
https://ncbi.nlm.nih.gov/pubmed/27470214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2016.49.9.125
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